DETAILS, FICTION AND P62

The interactions of p62 as well as UPS, autophagy and ubiquitinated proteins. Upon UPS inhibition, p62 is upregulated and phosphorylated on S405 and S409, that may facilitate the degradation of ubiquitinated cargoes through autophagy. p62 synthesis is induced by a rise in Nrf2 following UPS deficiency. The enhanced p62 competes with Nrf2 for Keap1,